Garland KM*, Sevimli S*, Kilchrist KV, Duvall CL, Cook RS, Wilson JT. Microparticle Depots for Controlled and Sustained Release of Endosomolytic Nanoparticles. Cellular and Molecular Bioengineering (2019) 

doi.org/10.1007/s12195-019-00571-6.

Part of 2019 CMBE Young Innovators special issue

Baljon JJ, Dandy A, Wang-Bishop L, Wehbe M, Jacobson ME, Wilson JT. The Efficiency of Cytosolic Drug Delivery Using Endosomolytic Polymers Does Not Correlate with Activation of the NLRP3 Inflammasome. Biomaterials Science 7:1888-1897 (2019).

Science.jpg

Wilson JT. A Sweeter Approach to Vaccine Design

Science. 363:584-584 (2019).

Nat Nano.jpg

Shae D, Becker KW, Chistov P, Yun D-S, Lytton-Jean A, Sevimli S, Ascano M, Kelley M, Johnson D, Balko J, Wilson JT. Endosomolytic Polymersomes Increase the Activity of Cyclic Dinucleotide STING Agonists to Enhance Cancer Immunotherapy. Nature Nanotechnology 14:269-278 (2019). 

see News & Views article:

Hubbell JA, Swartz MA. Trojan Horses for Immunotherapy. Nature Nanotechnology 14:196-197 (2019).

Biomat Science_Max.jpg

Jacobson ME, Wang-Bishop L, Becker KW, Wilson JT. Delivery of 5’-Triphosphate RNA with Endosomolytic Nanoparticles Potently Activates RIG-I to Improve Cancer ImmunotherapyBiomaterials Science. 7:547-559 (2019).

Elion D, Jacobson M, Hicks D, Rahman B, Sanchez V, Gonzalez-Ericsson P, Fedorova P, Pyle A, Wilson JT, Cook RS. Therapeutically active RIG-I agonist induces immunogenic tumor cell killing in breast cancersCancer Research. 78:6183-6195 (2018).

Feng.jpg

Qiu F, Becker KW, Knight FC, Baljon JJ, Shae D, Gilchuk P, Joyce S, Wilson JT. Poly(propylacrylic acid)-peptide nanoplexes as a platform for enhancing the immunogenicity of neoantigen cancer vaccinesBiomaterials.1 82:82-91 (2018).

Palmer.jpg

Palmer CR, Jacobson ME, Fedorova O, Pyle AM, Wilson JT. Environmentally Triggerable RIG-I Agonists Using Synthetic Polymer OverhangsBioconjugate Chemistry. 29:742-747 (2018). 

Sam.jpg

Sevimli S, Knight F, Gilchuk P, Joyce S, Wilson JT. Fatty Acid-Mimetic Micelles for Dual-Delivery of Antigens and Imidazoquinoline Adjuvants. ACS Biomaterials Science & Engineering. 3:179-194 (2017). 

May.jpg

Ou Y-C, Webb JA, Faley S, Shae D, Talbert EM, Lin S, Cutright C, Wilson JT, Bellan LM, Bardhan R. Gold Nanoantenna-Mediated Photothermal Drug Delivery from Thermosensitive Liposomes in Breast CancerACS Omega. 1:234-243 (2016). 

Ther Deliv.jpg

Shae D, Postma A, Wilson JT. Vaccine Delivery: Where Polymer Chemistry Meets Immunology. Therapeutic Delivery. 7:193-6 (2016).

Protocols.jpg

Gilchuk P, Knight FC, Wilson JT, Joyce S. (2016) “Eliciting epitope-specific CD8 T cell response by immunization with microbial proteinantigens formulated with alpha-galactosylceramide: theory, practice, & protocols.” In C.B. Fox ed. Methods in Molecular Biology: Vaccine Adjuvants — Methods and Protocols. New York, NY: Springer Science & Business Media, LLC.

TOF.jpg

Graham DJ, Wilson JT, Lai JJ, Stayton PS, Castner DG. 3D Localization of Polymer Nanoparticles in Cells Using ToF-SIMSBiointerphases.11:02A304 (2016). 

Joyce.jpg

Gilchuk P, Hill TM, Wilson JT, Joyce S. Discovering Protective CD8 T Cell Epitopes – No Single Immunologic Property Predicts It! Current Opinion in Immunology. 34:43-51 (2015). 

PolySci.jpg

Lane DD, Su FY, Chiu DY, Srinivasan S, Wilson JT, Ratner DM, Stayton PS, Convertine AJ. Dynamic Intracellular Delivery of Antibiotics via pH-Responsive PolymersomesPolymer Chemistry. 6:1255-1226 (2015).

Architecture.jpg

Wilson JT, Postma A, Keller S, Convertine AJ, Moad G, Rizzardo E, Chiefari J, Stayton PS. Enhancement of MHC-I Antigen Presentation via Architectural Control of pH-Responsive Endosomolytic Polymer Nanoparticles. The AAPS Journal. 17:358-369 (2015). 

Wilson JT, Postma A, Keller S, Convertine AJ, Moad G, Rizzardo E, Chiefari J, Stayton PS. Enhancement of MHC-I Antigen Presentation via Architectural Control of pH-Responsive Endosomolytic Polymer Nanoparticles. The AAPS Journal. 17:358-369 (2015). 

Wilson JT, Chaikof EL (2014). “Molecular Engineering of Cell and Tissue Surfaces with Polymer Thin Films.” In: Zhao W & Karp JM eds. Micro- and Nanoengineering the Cell Surface, 1st Edition.New York, NY: Elsevier.

Book.jpg
Salka.jpg

Keller S, Wilson JT, Patelia GI, Kern HB, Convertine AJ, Stayton PS. Neutral Polymer Micelle Carriers with pH-Responsive, Endosome-Releasing Activity Modulate Antigen Trafficking to Enhance CD8(+) T Cell ResponsesJournal of Controlled Release. 191:24-33 (2014).

ACS Nano.jpg

Wilson JT, Keller S, Manganiello MJ, Cheng C, Lee C-C, Opara C, Convertine AJ, Stayton PS. pH-Responsive Nanoparticle Vaccines for Dual-Delivery of Antigens and Immunostimulatory OligonucleotidesACS Nano. 7:3912-3925 (2013). 

Prior to 2013:

  1. Mets JM, Wilson JT, Cui W, Chaikof EL. An automated process for layer-by-layer assembly of polyelectrolyte multilayer thin films on viable cell aggregates. Advanced Healthcare Materials2:266-270 (2013)

  2. Stayton  PS, Ghosn B, Wilson JT(2012), “Finding the ‘Magic Bullet’: Targeting Carriers for Drug Delivery." In: Ratner BD, Hoffman AS, Schoen FJ, & Lemons JE eds. Biomaterials Science: An Introduction to Materials in Medicine, 3rd Edition. New York, NY: Elsevier/Academic Press.

  3. Wilson JT, Cui W, Kozlovskaya V, Kharlampieva E, Pan D, Qu Z, Mets J, Kumar V, Krishnamurthy V, Song Y, Tsukruk VV, Chaikof EL. Cell surface engineering with polyelectrolyte multilayer thin films. Journal of the American Chemical Society133:7054-64 (2011).

  4. Krishnamurthy VR, Wilson JT, Cui W, Song X, Lasanajak Y, Cummings RD, Chaikof EL. Chemoselective immobilization of peptides on abiotic and cell surfaces at controlled densities. Langmuir26:7675-8 (2010).

  5. Wilson JT, Haller CA, Qu Z, Cui W, Urlam MK, Chaikof EL. Biomolecular surface engineering of pancreatic islets with thrombmodulin.  Acta Biomaterialia6:1895-903 (2010).

  6. Wilson JT, Krishnamurthy VR, Qu Z, Cui W, Chaikof EL. Non-covalent cell surface engineering with cationic graft copolymers. Journal of the American Chemical Society51:18228-9 (2009).

  7. Cui W,Wilson JT, Wen J, Angsana J, Qu Z, Haller CA, Chaikof EL. Thrombomodulin improves early outcomes after intraportal islet transplantation. American Journal of Transplantation9: 1308-16 (2009).

  8. Wilson JT, Chaikof EL. Thrombosis and inflammation in intraportal islet transplantation: a review of pathophysiology and emerging therapeutics. Journal of Diabetes Science and Technology2: 746-59 (2008).

  9. Wilson JT, Cui W, Chaikof EL. Layer-by-layer assembly of a conformal nanothin PEG coating for intraportal islet transplantation. Nano Letters8: 1940-1948 (2008). (Highlighted in July 10, 2008 issue of Science-Business eXchange (SciBX), a Nature and BioCentury publication that focuses on translational research)

  10. Wilson JT, Chaikof EL. Challenges and emerging technologies in the immunoisolation of cells and tissues.Advanced Drug Delivery Reviews60: 124-45 (2008).

  11. Stabler CL, Sun X-L, Cui W, Wilson JT, Haller CA, Chaikof EL. Surface re-engineering of pancreatic islets with recombinant azido-thrombomodulin. Bioconjugate Chemistry 18: 1713-5 (2007). (cover article)

  12. Wilson JT, Cui W, Sun X-L, Tucker-Burden C, Weber CJ, Chaikof EL. In vivo biocompatibility and stability of a substrate-supported polymerizable membrane-mimetic film. Biomaterials28: 609-617 (2007).

  13. Dai Z, Wilson JT, Chaikof EL. Construction of PEGylated multilayer architectures via (strept)avidin/biotin interactions. Materials Science and Engineering C27: 402-408 (2007). 

  14. Bower CK, Parker JE, Higgins AZ, Oest ME, Wilson JT, Valentine BA, Bothwell MK, McGuire J. Protein antimicrobial barriers to bacterial adhesion: in vitroand in vivoevaluation of nisin-treated implantable materials. Colloids and Surfaces B: Biointerfaces25: 81-90 (2002).